The business and commercial center of Honduras is San Pedro Sula, whose leading choices for home-away-from-home comforts are stays at the Real InterContinental and Hilton Princess, although travelers looking for some quiet charm might enjoy the Isabella Boutique Hotel located in the Barrio Los Andes.

Fitting snugly into a valley at 3,000 ft., Tegucigalpa—more easily called Teguce by the locals—is the capital of Honduras; its narrow streets twist up and down hillsides, sheltering often charming pockets of colonial architecture.

Nicaragua is gaining a reputation as Central America’s most intriguing new travel destination.

The New York Times, in placing Panama in its No. 1 slot of 45 places to go in 2012, suggested: “Go for the canal. Stay for everything else.”

Where are travelers going to be going in 2013? Delta is betting that North Americans are going to continue their pursuit of discovery vacations in South America.

Big, brash and beautiful Buenos Aires is one of the world’s hottest destinations, in 2012 voted top South American city by Conde Nast Traveler readers.

Brazil’s inland futuristic capital Brasilia was carved out of nowhere in the 1950s, a stark, modernist and purpose-built city, and the only one in the world built in the 20th century that achieved UNESCO World Heritage status.

After winning bids to host both the 2014 World Cup soccer and the 2016 Summer Olympic Games, Rio de Janeiro—already a prized destination for American travelers—is solidly in the spotlight.

Because of its reputation as a concrete metropolis, visitors are surprised by Sao Paulo’s lovely natural areas.

Centerpiece of the Central Valley, Santiago is home to a third of Chilean people.